Leveraging information between multiple population groups and traits improves fine-mapping resolution

Statistical fine-mapping helps to pinpoint likely causal variants underlying genetic association signals. Its resolution can be improved by (i) leveraging information between traits; and (ii) exploiting differences in linkage disequilibrium structure between diverse population groups. Using associat...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Feng, Soremekun, Opeyemi, Chikowore, Tinashe, Fatumo, Segun, Barroso, Inês, Morris, Andrew P., Asimit, Jennifer L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638399/
https://www.ncbi.nlm.nih.gov/pubmed/37949886
http://dx.doi.org/10.1038/s41467-023-43159-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638399/
https://www.ncbi.nlm.nih.gov/pubmed/37949886
http://dx.doi.org/10.1038/s41467-023-43159-5

Ejemplares similares