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Drug screen identifies verteporfin as a regulator of lipid metabolism in macrophage foam cells

Arterial macrophage foam cells are filled with cholesterol ester (CE) stored in cytosolic lipid droplets (LDs). Foam cells are central players in progression of atherosclerosis as regulators of lipid metabolism and inflammation, two major driving forces of atherosclerosis development. Thus, foam cel...

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Detalles Bibliográficos
Autores principales: Hoeffner, Nicholas, Paul, Antoni, Goo, Young-Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638409/
https://www.ncbi.nlm.nih.gov/pubmed/37949969
http://dx.doi.org/10.1038/s41598-023-46467-4