Miriplatin-loaded liposome, as a novel mitophagy inducer, suppresses pancreatic cancer proliferation through blocking POLG and TFAM-mediated mtDNA replication

Pancreatic cancer is a more aggressive and refractory malignancy. Resistance and toxicity limit drug efficacy. Herein, we report a lower toxic and higher effective miriplatin (MPt)-loaded liposome, LMPt, exhibiting totally different anti-cancer mechanism from previously reported platinum agents. Bot...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Xiaowei, Wang, Mengyan, Cai, Meilian, Shao, Rongguang, Xia, Guimin, Zhao, Wuli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638513/
https://www.ncbi.nlm.nih.gov/pubmed/37969736
http://dx.doi.org/10.1016/j.apsb.2023.07.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638513/
https://www.ncbi.nlm.nih.gov/pubmed/37969736
http://dx.doi.org/10.1016/j.apsb.2023.07.009

Ejemplares similares