Activation of PXR causes drug interactions with Paxlovid in transgenic mice

Paxlovid is a nirmatrelvir (NMV) and ritonavir (RTV) co-packaged medication used for the treatment of coronavirus disease 2019 (COVID-19). The active component of Paxlovid is NMV and RTV is a pharmacokinetic booster. Our work aimed to investigate the drug/herb–drug interactions associated with Paxlo...

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Detalles Bibliográficos
Autores principales: Lei, Saifei, Guo, Alice, Lu, Jie, Qi, Qian, Devanathan, Aaron S., Zhu, Junjie, Ma, Xiaochao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638548/
https://www.ncbi.nlm.nih.gov/pubmed/37969744
http://dx.doi.org/10.1016/j.apsb.2023.08.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638548/
https://www.ncbi.nlm.nih.gov/pubmed/37969744
http://dx.doi.org/10.1016/j.apsb.2023.08.001

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