Impact of bound ssRNA length on allostery in the Dengue Virus NS3 helicase

The presence of ATP is known to stimulate helicase activity of the Dengue Virus Non-structural protein 3 helicase (NS3h), and the presence of RNA stimulates NS3h ATPase activity, however this coupling is still mechanistically unclear. Here we use atomistic models and molecular dynamics simulations t...

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Detalles Bibliográficos
Autores principales: Amrein, Fernando, Sarto, Carolina, Cababie, Leila A, Gonzalez Flecha, F Luis, Kaufman, Sergio B, Arrar, Mehrnoosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10639040/
https://www.ncbi.nlm.nih.gov/pubmed/37823592
http://dx.doi.org/10.1093/nar/gkad808

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10639040/
https://www.ncbi.nlm.nih.gov/pubmed/37823592
http://dx.doi.org/10.1093/nar/gkad808

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