Atomistic structure of the SARS-CoV-2 pseudoknot in solution from SAXS-driven molecular dynamics

SARS-CoV-2 depends on −1 programmed ribosomal frameshifting (−1 PRF) to express proteins essential for its replication. The RNA pseudoknot stimulating −1 PRF is thus an attractive drug target. However, the structural models of this pseudoknot obtained from cryo-EM and crystallography differ in some...

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Detalles Bibliográficos
Autores principales: He, Weiwei, San Emeterio, Josue, Woodside, Michael T, Kirmizialtin, Serdal, Pollack, Lois
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10639041/
https://www.ncbi.nlm.nih.gov/pubmed/37819014
http://dx.doi.org/10.1093/nar/gkad809

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10639041/
https://www.ncbi.nlm.nih.gov/pubmed/37819014
http://dx.doi.org/10.1093/nar/gkad809

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