Unprecedented reactivity of polyamines with aldehydic DNA modifications: structural determinants of reactivity, characterization and enzymatic stability of adducts

Apurinic/apyrimidinic (AP) sites, 5-formyluracil (fU) and 5-formylcytosine (fC) are abundant DNA modifications that share aldehyde-type reactivity. Here, we demonstrate that polyamines featuring at least one secondary 1,2-diamine fragment in combination with aromatic units form covalent DNA adducts...

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Detalles Bibliográficos
Autores principales: Gusti Ngurah Putu, Eka Putra, Cattiaux, Laurent, Lavergne, Thomas, Pommier, Yves, Bombard, Sophie, Granzhan, Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10639052/
https://www.ncbi.nlm.nih.gov/pubmed/37850658
http://dx.doi.org/10.1093/nar/gkad837

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10639052/
https://www.ncbi.nlm.nih.gov/pubmed/37850658
http://dx.doi.org/10.1093/nar/gkad837

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