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Unprecedented reactivity of polyamines with aldehydic DNA modifications: structural determinants of reactivity, characterization and enzymatic stability of adducts
Apurinic/apyrimidinic (AP) sites, 5-formyluracil (fU) and 5-formylcytosine (fC) are abundant DNA modifications that share aldehyde-type reactivity. Here, we demonstrate that polyamines featuring at least one secondary 1,2-diamine fragment in combination with aromatic units form covalent DNA adducts...
Autores principales: | Gusti Ngurah Putu, Eka Putra, Cattiaux, Laurent, Lavergne, Thomas, Pommier, Yves, Bombard, Sophie, Granzhan, Anton |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10639052/ https://www.ncbi.nlm.nih.gov/pubmed/37850658 http://dx.doi.org/10.1093/nar/gkad837 |
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