Cargando…
Immunoprecipitation of RNA–DNA hybrid interacting proteins in Trypanosoma brucei reveals conserved and novel activities, including in the control of surface antigen expression needed for immune evasion by antigenic variation
RNA–DNA hybrids are epigenetic features of genomes that provide a diverse and growing range of activities. Understanding of these functions has been informed by characterising the proteins that interact with the hybrids, but all such analyses have so far focused on mammals, meaning it is unclear if...
Autores principales: | Girasol, Mark J, Briggs, Emma M, Marques, Catarina A, Batista, José M, Beraldi, Dario, Burchmore, Richard, Lemgruber, Leandro, McCulloch, Richard |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10639054/ https://www.ncbi.nlm.nih.gov/pubmed/37843098 http://dx.doi.org/10.1093/nar/gkad836 |
Ejemplares similares
-
Trypanosoma brucei ribonuclease H2A is an essential R-loop processing enzyme whose loss causes DNA damage during transcription initiation and antigenic variation
por: Briggs, Emma, et al.
Publicado: (2019) -
Genome maintenance functions of a putative Trypanosoma brucei translesion DNA polymerase include telomere association and a role in antigenic variation
por: Leal, Andrea Zurita, et al.
Publicado: (2020) -
Diverged composition and regulation of the Trypanosoma brucei origin recognition complex that mediates DNA replication initiation
por: Marques, Catarina A., et al.
Publicado: (2016) -
RAD51-mediated R-loop formation acts to repair transcription-associated DNA breaks driving antigenic variation in Trypanosoma brucei
por: Girasol, Mark John, et al.
Publicado: (2023) -
Single molecule analysis of Trypanosoma brucei DNA replication dynamics
por: Calderano, Simone Guedes, et al.
Publicado: (2015)