Inhibition of CDK12 elevates cancer cell dependence on P-TEFb by stimulation of RNA polymerase II pause release

P-TEFb and CDK12 facilitate transcriptional elongation by RNA polymerase II. Given the prominence of both kinases in cancer, gaining a better understanding of their interplay could inform the design of novel anti-cancer strategies. While down-regulation of DNA repair genes in CDK12-targeted cancer c...

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Detalles Bibliográficos
Autores principales: Wang, Zhijia, Himanen, Samu V, Haikala, Heidi M, Friedel, Caroline C, Vihervaara, Anniina, Barborič, Matjaž
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10639066/
https://www.ncbi.nlm.nih.gov/pubmed/37811895
http://dx.doi.org/10.1093/nar/gkad792

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10639066/
https://www.ncbi.nlm.nih.gov/pubmed/37811895
http://dx.doi.org/10.1093/nar/gkad792

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