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Inhibition of CDK12 elevates cancer cell dependence on P-TEFb by stimulation of RNA polymerase II pause release

P-TEFb and CDK12 facilitate transcriptional elongation by RNA polymerase II. Given the prominence of both kinases in cancer, gaining a better understanding of their interplay could inform the design of novel anti-cancer strategies. While down-regulation of DNA repair genes in CDK12-targeted cancer c...

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Detalles Bibliográficos
Autores principales:	Wang, Zhijia, Himanen, Samu V, Haikala, Heidi M, Friedel, Caroline C, Vihervaara, Anniina, Barborič, Matjaž
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10639066/ https://www.ncbi.nlm.nih.gov/pubmed/37811895 http://dx.doi.org/10.1093/nar/gkad792

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