Alternative splicing of BCL-x is controlled by RBM25 binding to a G-quadruplex in BCL-x pre-mRNA

BCL-x is a master regulator of apoptosis whose pre-mRNA is alternatively spliced into either a long (canonical) anti-apoptotic Bcl-xL isoform, or a short (alternative) pro-apoptotic Bcl-xS isoform. The balance between these two antagonistic isoforms is tightly regulated and overexpression of Bcl-xL...

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Detalles Bibliográficos
Autores principales: Le Sénéchal, Ronan, Keruzoré, Marc, Quillévéré, Alicia, Loaëc, Nadège, Dinh, Van-Trang, Reznichenko, Oksana, Guixens-Gallardo, Pedro, Corcos, Laurent, Teulade-Fichou, Marie-Paule, Granzhan, Anton, Blondel, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10639069/
https://www.ncbi.nlm.nih.gov/pubmed/37811881
http://dx.doi.org/10.1093/nar/gkad772

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10639069/
https://www.ncbi.nlm.nih.gov/pubmed/37811881
http://dx.doi.org/10.1093/nar/gkad772

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