A sensor complements the steric gate when DNA polymerase ϵ discriminates ribonucleotides

The cellular imbalance between high concentrations of ribonucleotides (NTPs) and low concentrations of deoxyribonucleotides (dNTPs), is challenging for DNA polymerases when building DNA from dNTPs. It is currently believed that DNA polymerases discriminate against NTPs through a steric gate model in...

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Detalles Bibliográficos
Autores principales: Parkash, Vimal, Kulkarni, Yashraj, Bylund, Göran O, Osterman, Pia, Kamerlin, Shina Caroline Lynn, Johansson, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10639073/
https://www.ncbi.nlm.nih.gov/pubmed/37819038
http://dx.doi.org/10.1093/nar/gkad817

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10639073/
https://www.ncbi.nlm.nih.gov/pubmed/37819038
http://dx.doi.org/10.1093/nar/gkad817

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