Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor

β-arrestins play a key role in G protein–coupled receptor (GPCR) internalization, trafficking, and signaling. Whether β-arrestins act independently of G protein–mediated signaling has not been fully elucidated. Studies using genome-editing approaches revealed that whereas G proteins are essential fo...

Descripción completa

Detalles Bibliográficos
Autores principales: Burghi, Valeria, Paradis, Justine S., Officer, Adam, Adame-Garcia, Sendi Rafael, Wu, Xingyu, Matthees, Edda S.F., Barsi-Rhyne, Benjamin, Ramms, Dana J., Clubb, Lauren, Acosta, Monica, Tamayo, Pablo, Bouvier, Michel, Inoue, Asuka, von Zastrow, Mark, Hoffmann, Carsten, Gutkind, J. Silvio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641165/
https://www.ncbi.nlm.nih.gov/pubmed/37774973
http://dx.doi.org/10.1016/j.jbc.2023.105293

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641165/
https://www.ncbi.nlm.nih.gov/pubmed/37774973
http://dx.doi.org/10.1016/j.jbc.2023.105293

Ejemplares similares