Sequence tolerance of immunoglobulin variable domain framework regions to noncanonical intradomain disulfide linkages

Most immunoglobulin (Ig) domains bear only a single highly conserved canonical intradomain, inter-β-sheet disulfide linkage formed between Cys23-Cys104, and incorporation of rare noncanonical disulfide linkages at other locations can enhance Ig domain stability. Here, we exhaustively surveyed the se...

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Detalles Bibliográficos
Autores principales: Kim, Dae Young, Kandalaft, Hiba, Lowden, Michael J., Yang, Qingling, Rossotti, Martin A., Robotham, Anna, Kelly, John F., Hussack, Greg, Schrag, Joseph D., Henry, Kevin A., Tanha, Jamshid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641266/
https://www.ncbi.nlm.nih.gov/pubmed/37742917
http://dx.doi.org/10.1016/j.jbc.2023.105278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641266/
https://www.ncbi.nlm.nih.gov/pubmed/37742917
http://dx.doi.org/10.1016/j.jbc.2023.105278

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