Cargando…

Sequence tolerance of immunoglobulin variable domain framework regions to noncanonical intradomain disulfide linkages

Most immunoglobulin (Ig) domains bear only a single highly conserved canonical intradomain, inter-β-sheet disulfide linkage formed between Cys23-Cys104, and incorporation of rare noncanonical disulfide linkages at other locations can enhance Ig domain stability. Here, we exhaustively surveyed the se...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Dae Young, Kandalaft, Hiba, Lowden, Michael J., Yang, Qingling, Rossotti, Martin A., Robotham, Anna, Kelly, John F., Hussack, Greg, Schrag, Joseph D., Henry, Kevin A., Tanha, Jamshid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641266/ https://www.ncbi.nlm.nih.gov/pubmed/37742917 http://dx.doi.org/10.1016/j.jbc.2023.105278

Ejemplares similares

Stability-Diversity Tradeoffs Impose Fundamental Constraints on Selection of Synthetic Human V(H)/V(L) Single-Domain Antibodies from In Vitro Display Libraries
por: Henry, Kevin A., et al.
Publicado: (2017)

Intradomain Confinement of Disulfides in the Folding of Two Consecutive Modules of the LDL Receptor
por: Martínez-Oliván, Juan, et al.
Publicado: (2015)

Structure-guided design of a potent Clostridioides difficile toxin A inhibitor
por: Hussack, Greg, et al.
Publicado: (2023)

Corrigendum: Structure-guided design of a potent Clostridioides difficile toxin A inhibitor
por: Hussack, Greg, et al.
Publicado: (2023)

Stabilisation of the Fc Fragment of Human IgG1 by Engineered Intradomain Disulfide Bonds
por: Wozniak-Knopp, Gordana, et al.
Publicado: (2012)

Toxin-Specific Antibodies for the Treatment of Clostridium difficile: Current Status and Future Perspectives (†)
por: Hussack, Greg, et al.
Publicado: (2010)

An update on antibody-based immunotherapies for Clostridium difficile infection
por: Hussack, Greg, et al.
Publicado: (2016)

Neutralization of Clostridium difficile toxin B with V(H)H-Fc fusions targeting the delivery and CROPs domains
por: Hussack, Greg, et al.
Publicado: (2018)

Targeting surface-layer proteins with single-domain antibodies: a potential therapeutic approach against Clostridium difficile-associated disease
por: Kandalaft, Hiba, et al.
Publicado: (2015)

Nitric oxide activates intradomain disulfide bond formation in the kinase loop of Akt1/PKBα after burn injury
por: LU, X.-M., et al.
Publicado: (2013)

Fine mapping of epitopes by intradomain Kd/Dd recombinants
Publicado: (1987)

Engineered Single-Domain Antibodies with High Protease Resistance and Thermal Stability
por: Hussack, Greg, et al.
Publicado: (2011)

Application of Assisted Design of Antibody and Protein Therapeutics (ADAPT) improves efficacy of a Clostridium difficile toxin A single-domain antibody
por: Sulea, Traian, et al.
Publicado: (2018)

Multivalent Anchoring and Oriented Display of Single-Domain Antibodies on Cellulose
por: Hussack, Greg, et al.
Publicado: (2009)

Single-Domain Antibodies Represent Novel Alternatives to Monoclonal Antibodies as Targeting Agents against the Human Papillomavirus 16 E6 Protein
por: Togtema, Melissa, et al.
Publicado: (2019)

Antibody light chain variable domains and their biophysically improved versions for human immunotherapy
por: Kim, Dae Young, et al.
Publicado: (2014)

Isolation and characterization of camelid single-domain antibodies against HER2
por: Hussack, Greg, et al.
Publicado: (2018)

Noncanonical IFN Signaling: Mechanistic Linkage of Genetic and Epigenetic Events
por: Johnson, Howard M., et al.
Publicado: (2016)

trans-Acting Arginine Residues in the AAA+ Chaperone ClpB Allosterically Regulate the Activity through Inter- and Intradomain Communication
por: Zeymer, Cathleen, et al.
Publicado: (2014)

Direct mass spectrometric characterization of disulfide linkages
por: Guan, Xiaoyan, et al.
Publicado: (2018)

The myelin-associated glycoproteins: membrane disposition, evidence of a novel disulfide linkage between immunoglobulin-like domains, and posttranslational palmitylation
Publicado: (1990)

Cocrystallization of ubiquitin–deubiquitinase complexes through disulfide linkage
por: Negron Teron, Kristos I., et al.
Publicado: (2023)

Arsenal of nanobodies shows broad-spectrum neutralization against SARS-CoV-2 variants of concern in vitro and in vivo in hamster models
por: Rossotti, Martin A., et al.
Publicado: (2022)

Steric and stereoscopic disulfide construction for cross-linkage via N-dithiophthalimides
por: Gao, Wen-Chao, et al.
Publicado: (2020)

Influence of variant-specific mutations, temperature and pH on conformations of a large set of SARS-CoV-2 spike trimer vaccine antigen candidates
por: Stuible, Matthew, et al.
Publicado: (2023)

Noncanonical hamiltonian mechanics
por: Littlejohn, R G
Publicado: (1986)

Noncanonical Reactions of Flavoenzymes
por: Sobrado, Pablo
Publicado: (2012)

Mahogunin-mediated α-tubulin ubiquitination via noncanonical K6 linkage regulates microtubule stability and mitotic spindle orientation
por: Srivastava, D, et al.
Publicado: (2014)

Disulfide isomerization reactions in titin immunoglobulin domains enable a mode of protein elasticity
por: Giganti, David, et al.
Publicado: (2018)

Noncanonical Roles of RAD51
por: Thomas, Mélissa, et al.
Publicado: (2023)

β(2)-microglobulin forms 3D domain-swapped amyloid fibrils with disulfide linkages
por: Liu, Cong, et al.
Publicado: (2010)

A deeply conserved, noncanonical miRNA hosted by ribosomal DNA
por: Chak, Li-Ling, et al.
Publicado: (2015)

pH and Redox-Dual Sensitive Chitosan Nanoparticles Having Methyl Ester and Disulfide Linkages for Drug Targeting against Cholangiocarcinoma Cells
por: Yang, Ju-Il, et al.
Publicado: (2022)

Isolation and characterization of a VHH targeting the Acinetobacter baumannii cell surface protein CsuA/B
por: Lei, Eric K., et al.
Publicado: (2023)

Hard nut to crack: Solving the disulfide linkage pattern of the Neosartorya (Aspergillus) fischeri antifungal protein 2
por: Váradi, Györgyi, et al.
Publicado: (2023)

Noncanonical NF-κB in Cancer
por: Tegowski, Matthew, et al.
Publicado: (2018)

Noncanonical Ion Channel Behaviour in Pain
por: Ciotu, Cosmin I., et al.
Publicado: (2019)

The noncanonical role of EZH2 in cancer
por: Huang, Jinhua, et al.
Publicado: (2021)

Genetic linkage of the cytolytic T lymphocyte repertoire and immunoglobulin heavy chain genes
Publicado: (1982)

Redox and pH Responsive Poly (Amidoamine) Dendrimer-Heparin Conjugates via Disulfide Linkages for Letrozole Delivery
por: Nguyen, Thanh Luan, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_9m9go6gnofd0641t3v8uf58oi4