Investigation of novel bis-thiadiazole bearing schiff base derivatives as effective inhibitors of thymidine phosphorylase: Synthesis, in vitro bioactivity and molecular docking study

Thymidine phosphorylase (TP) is an angiogenic enzyme. It is crucial for the development, invasion and metastasis of tumors as well as angiogenesis. In our current research, we examine how structurally changing bis-thiadiazole bearing bis-schiff bases affects their ability to inhibit TP. Through the...

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Detalles Bibliográficos
Autores principales: Hussain, Rafaqat, Rehman, Wajid, Khan, Shoaib, Jaber, Fadi, Rahim, Fazal, Shah, Mazloom, Khan, Yousaf, Iqbal, Shahid, Naz, Haseena, Khan, Imran, Issa Alahmdi, Mohammed, Awwad, Nasser S., Ibrahium, Hala A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641276/
https://www.ncbi.nlm.nih.gov/pubmed/37965293
http://dx.doi.org/10.1016/j.jsps.2023.101823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641276/
https://www.ncbi.nlm.nih.gov/pubmed/37965293
http://dx.doi.org/10.1016/j.jsps.2023.101823

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