Cargando…

High expression of focal adhesion kinase (p125(FAK)) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome

INTRODUCTION: Focal adhesion kinase (FAK) regulates multiple cellular processes including growth, differentiation, adhesion, motility and apoptosis. In breast carcinoma, FAK overexpression has been linked to cancer progression but the prognostic relevance remains unknown. In particular, with regard...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schmitz, Klaus Jürgen, Grabellus, Florian, Callies, Rainer, Otterbach, Friedrich, Wohlschlaeger, Jeremias, Levkau, Bodo, Kimmig, Rainer, Schmid, Kurt Werner, Baba, Hideo Andreas
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2005
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1064131/ https://www.ncbi.nlm.nih.gov/pubmed/15743500 http://dx.doi.org/10.1186/bcr977

Ejemplares similares

Caspase-mediated Cleavage of Focal Adhesion Kinase pp125(FAK) and Disassembly of Focal Adhesions in Human Endothelial Cell Apoptosis
por: Levkau, Bodo, et al.
Publicado: (1998)

Degraded Collagen Fragments Promote Rapid Disassembly of Smooth Muscle Focal Adhesions That Correlates with Cleavage of Pp125(FAK), Paxillin, and Talin
por: Carragher, Neil O., et al.
Publicado: (1999)

Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions
Publicado: (1993)

Direct association of pp125FAK with paxillin, the focal adhesion- targeting mechanism of pp125FAK
Publicado: (1995)

Focal adhesion kinase (FAK) expression and activation during lens development
por: Kokkinos, Maria I., et al.
Publicado: (2007)

Simiate and the focal adhesion kinase FAK1 cooperate in the regulation of dendritogenesis
por: Rama, Ramya, et al.
Publicado: (2022)

Focal Adhesion Kinase (FAK) tyrosine 397E mutation restores the vascular leakage defect in endothelium‐specific FAK‐kinase dead mice
por: Alexopoulou, Annika N, et al.
Publicado: (2017)

HER-2/neu diagnostics in breast cancer
por: Carney, Walter P, et al.
Publicado: (2007)

ZINC40099027 activates human focal adhesion kinase by accelerating the enzymatic activity of the FAK kinase domain
por: Rashmi,, et al.
Publicado: (2021)

Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets
Publicado: (1992)

Morphological and Molecular Changes of the Myocardium After Left Ventricular Mechanical Support
por: Baba, Hideo A, et al.
Publicado: (2008)

Paxillin and Focal Adhesion Kinase (FAK) Regulate Cardiac Contractility in the Zebrafish Heart
por: Hirth, Sofia, et al.
Publicado: (2016)

The roles of nuclear focal adhesion kinase (FAK) on Cancer: a focused review
por: Zhou, Jin, et al.
Publicado: (2019)

T cell receptor- and beta 1 integrin-mediated signals synergize to induce tyrosine phosphorylation of focal adhesion kinase (pp125FAK) in human T cells
Publicado: (1995)

SAT-574 Elucidating the Role of Nuclear Focal Adhesion Kinase (FAK) in Thyroid Cancer
por: Kellett, Meghan, et al.
Publicado: (2019)

Focal Adhesion Kinase (FAK) Over-Expression and Prognostic Implication in Pediatric Hepatocellular Carcinoma
por: Francalanci, Paola, et al.
Publicado: (2020)

Drug Discovery Targeting Focal Adhesion Kinase (FAK) as a Promising Cancer Therapy
por: Pang, Xiao-Jing, et al.
Publicado: (2021)

The direct effect of Focal Adhesion Kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis
por: Golubovskaya, Vita M, et al.
Publicado: (2009)

Downregulation of Focal Adhesion Kinase (FAK) by cord blood stem cells inhibits angiogenesis in glioblastoma
por: Dasari, Venkata Ramesh, et al.
Publicado: (2010)

Identification of Novel Focal Adhesion Kinase Substrates: Role for FAK in NFκB Signaling
por: Dwyer, Sheila Figel, et al.
Publicado: (2015)

Prognostic Value of Focal Adhesion Kinase (FAK) in Human Solid Carcinomas: A Meta-Analysis
por: Zeng, Xiao-Qing, et al.
Publicado: (2016)

Daurinol blocks breast and lung cancer metastasis and development by inhibition of focal adhesion kinase (FAK)
por: Woo, Jong Kyu, et al.
Publicado: (2017)

Focal Adhesion Kinase (FAK) Inhibition Synergizes with KRAS G12C Inhibitors in Treating Cancer through the Regulation of the FAK–YAP Signaling
por: Zhang, Baoyuan, et al.
Publicado: (2021)

Elevated expression of cyclooxygenase-2 is a negative prognostic factor for overall survival in intrahepatic cholangiocarcinoma
por: Schmitz, Klaus Jürgen, et al.
Publicado: (2006)

FAK Family Kinases in Vascular Diseases
por: Murphy, James M., et al.
Publicado: (2020)

RANTES induces tyrosine kinase activity of stably complexed p125FAK and ZAP-70 in human T cells
Publicado: (1996)

Specific induction of pp125 focal adhesion kinase in human breast cancer
por: Watermann, D O, et al.
Publicado: (2005)

Molecular dynamics simulation analysis of Focal Adhesive Kinase (FAK) docked with solanesol as an anti-cancer agent
por: Daneial, Betty, et al.
Publicado: (2017)

Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells
por: Rigiracciolo, Damiano Cosimo, et al.
Publicado: (2019)

Mycosporine-Like Amino Acids Promote Wound Healing through Focal Adhesion Kinase (FAK) and Mitogen-Activated Protein Kinases (MAP Kinases) Signaling Pathway in Keratinocytes
por: Choi, Yun-Hee, et al.
Publicado: (2015)

β1 Integrin-Focal Adhesion Kinase (FAK) Signaling Modulates Retinal Ganglion Cell (RGC) Survival
por: Santos, Andrea Rachelle C., et al.
Publicado: (2012)

Vascular growth responses to chronic arterial occlusion are unaffected by myeloid specific focal adhesion kinase (FAK) deletion
por: Heuslein, Joshua L., et al.
Publicado: (2016)

Carcinoma of an unknown primary: are EGF receptor, Her-2/neu, and c-Kit tyrosine kinases potential targets for therapy?
por: Massard, C, et al.
Publicado: (2007)

Carcinoma of an unknown primary: are EGF receptor, Her-2/neu, and c-Kit tyrosine kinases potential targets for therapy?
por: Massard, C, et al.
Publicado: (2008)

Small Molecule Tyrosine Kinase Inhibitors of ErbB2/HER2/Neu in the Treatment of Aggressive Breast Cancer
por: Schroeder, Richard L., et al.
Publicado: (2014)

Breast Cancer and Her-2/Neu
por: Sherwood, Roy
Publicado: (2005)

Focal adhesion kinase-related non-kinase ameliorates liver fibrosis by inhibiting aerobic glycolysis via the FAK/Ras/c-myc/ENO1 pathway
por: Huang, Tao, et al.
Publicado: (2022)

Staurosporine, an inhibitor of hormonally up-regulated neu-associated kinase
por: Zambrano, Joelle N., et al.
Publicado: (2018)

The Clinical Importance of the Heterogeneity of HER2 neu
por: Davila, Enrique, et al.
Publicado: (2010)

Activation of the integrins α5β1 and αvβ3 and focal adhesion kinase (FAK) during arteriogenesis
por: Cai, Wei-Jun, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_jksa9nckfmrq385075e3nfh2sh