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Structural insights of the p97/VCP AAA+ ATPase: How adapter interactions coordinate diverse cellular functionality

p97/valosin-containing protein is an essential eukaryotic AAA+ ATPase with diverse functions including protein homeostasis, membrane remodeling, and chromatin regulation. Dysregulation of p97 function causes severe neurodegenerative disease and is associated with cancer, making this protein a signif...

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Detalles Bibliográficos
Autores principales: Braxton, Julian R., Southworth, Daniel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641518/
https://www.ncbi.nlm.nih.gov/pubmed/37611827
http://dx.doi.org/10.1016/j.jbc.2023.105182