Ligand Sulfur Oxidation State Progressively Alters Galectin-3-Ligand Complex Conformations To Induce Affinity-Influencing Hydrogen Bonds

[Image: see text] Galectins play biological roles in immune regulation and tumor progression. Ligands with high affinity for the shallow, hydrophilic galectin-3 ligand binding site rely primarily on a galactose core with appended aryltriazole moieties, making hydrophobic interactions and π-stacking....

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Detalles Bibliográficos
Autores principales: Mahanti, Mukul, Pal, Kumar Bhaskar, Kumar, Rohit, Schulze, Markus, Leffler, Hakon, Logan, Derek T., Nilsson, Ulf J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641817/
https://www.ncbi.nlm.nih.gov/pubmed/37878264
http://dx.doi.org/10.1021/acs.jmedchem.3c01223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641817/
https://www.ncbi.nlm.nih.gov/pubmed/37878264
http://dx.doi.org/10.1021/acs.jmedchem.3c01223

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