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Ligand Sulfur Oxidation State Progressively Alters Galectin-3-Ligand Complex Conformations To Induce Affinity-Influencing Hydrogen Bonds

[Image: see text] Galectins play biological roles in immune regulation and tumor progression. Ligands with high affinity for the shallow, hydrophilic galectin-3 ligand binding site rely primarily on a galactose core with appended aryltriazole moieties, making hydrophobic interactions and π-stacking....

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Detalles Bibliográficos
Autores principales:	Mahanti, Mukul, Pal, Kumar Bhaskar, Kumar, Rohit, Schulze, Markus, Leffler, Hakon, Logan, Derek T., Nilsson, Ulf J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641817/ https://www.ncbi.nlm.nih.gov/pubmed/37878264 http://dx.doi.org/10.1021/acs.jmedchem.3c01223

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