Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation

[Image: see text] Dysregulation of both tubulin deacetylases sirtuin 2 (Sirt2) and the histone deacetylase 6 (HDAC6) has been associated with the pathogenesis of cancer and neurodegeneration, thus making these two enzymes promising targets for pharmaceutical intervention. Herein, we report the desig...

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Detalles Bibliográficos
Autores principales: Sinatra, Laura, Vogelmann, Anja, Friedrich, Florian, Tararina, Margarita A., Neuwirt, Emilia, Colcerasa, Arianna, König, Philipp, Toy, Lara, Yesiloglu, Talha Z., Hilscher, Sebastian, Gaitzsch, Lena, Papenkordt, Niklas, Zhai, Shiyang, Zhang, Lin, Romier, Christophe, Einsle, Oliver, Sippl, Wolfgang, Schutkowski, Mike, Gross, Olaf, Bendas, Gerd, Christianson, David W., Hansen, Finn K., Jung, Manfred, Schiedel, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641818/
https://www.ncbi.nlm.nih.gov/pubmed/37902787
http://dx.doi.org/10.1021/acs.jmedchem.3c01385

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641818/
https://www.ncbi.nlm.nih.gov/pubmed/37902787
http://dx.doi.org/10.1021/acs.jmedchem.3c01385

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