Cargando…
Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation
[Image: see text] Dysregulation of both tubulin deacetylases sirtuin 2 (Sirt2) and the histone deacetylase 6 (HDAC6) has been associated with the pathogenesis of cancer and neurodegeneration, thus making these two enzymes promising targets for pharmaceutical intervention. Herein, we report the desig...
Autores principales: | Sinatra, Laura, Vogelmann, Anja, Friedrich, Florian, Tararina, Margarita A., Neuwirt, Emilia, Colcerasa, Arianna, König, Philipp, Toy, Lara, Yesiloglu, Talha Z., Hilscher, Sebastian, Gaitzsch, Lena, Papenkordt, Niklas, Zhai, Shiyang, Zhang, Lin, Romier, Christophe, Einsle, Oliver, Sippl, Wolfgang, Schutkowski, Mike, Gross, Olaf, Bendas, Gerd, Christianson, David W., Hansen, Finn K., Jung, Manfred, Schiedel, Matthias |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641818/ https://www.ncbi.nlm.nih.gov/pubmed/37902787 http://dx.doi.org/10.1021/acs.jmedchem.3c01385 |
Ejemplares similares
-
Development of a NanoBRET assay to validate inhibitors of Sirt2-mediated lysine deacetylation and defatty-acylation that block prostate cancer cell migration
por: Vogelmann, A., et al.
Publicado: (2022) -
First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement
por: Herp, Daniel, et al.
Publicado: (2022) -
Discovery of dual tubulin-NEDDylation inhibitors with antiproliferative activity
por: Fu, Dong-Jun, et al.
Publicado: (2022) -
Deacetylation of α-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly
por: Ran, Jie, et al.
Publicado: (2015) -
NDST3 deacetylates α‐tubulin and suppresses V‐ATPase assembly and lysosomal acidification
por: Tang, Qing, et al.
Publicado: (2021)