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Addressing Motor Dysfunction by a Selective α6-Containing Nicotinic Receptor Antagonist
In the striatum, presynaptic α6-containig nicotinic receptors are crucially involved in the modulation of dopamine release. CVN417, a novel selective antagonist at this receptor subtype, attenuates motor dysfunction in a Parkinson’s disease-relevant animal model, suggesting, for this pathology, a th...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641822/ https://www.ncbi.nlm.nih.gov/pubmed/37852222 http://dx.doi.org/10.1021/acs.jmedchem.3c01817 |