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Addressing Motor Dysfunction by a Selective α6-Containing Nicotinic Receptor Antagonist

In the striatum, presynaptic α6-containig nicotinic receptors are crucially involved in the modulation of dopamine release. CVN417, a novel selective antagonist at this receptor subtype, attenuates motor dysfunction in a Parkinson’s disease-relevant animal model, suggesting, for this pathology, a th...

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Detalles Bibliográficos
Autores principales: Bolchi, Cristiano, Pallavicini, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641822/
https://www.ncbi.nlm.nih.gov/pubmed/37852222
http://dx.doi.org/10.1021/acs.jmedchem.3c01817