First Optimization of Novel, Potent, Selective PDE11A4 Inhibitors for Age-Related Cognitive Decline

[Image: see text] Phosphodiesterase 11A4 (PDE11A4) is a dual-acting cyclic nucleotide hydrolase expressed in neurons in the CA1, subiculum, amygdalostriatal transition area and amygdalohippocampal area of the extended hippocampal formation. PDE11A4 is the only PDE enzyme to emanate solely from hippo...

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Detalles Bibliográficos
Autores principales: Mahmood, Shams ul, Lozano Gonzalez, Mariana, Tummalapalli, Sreedhar, Eberhard, Jeremy, Ly, Judy, Hoffman, Charles S., Kelly, Michy P., Gordon, John, Colussi, Dennis, Childers, Wayne, Rotella, David P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641827/
https://www.ncbi.nlm.nih.gov/pubmed/37862143
http://dx.doi.org/10.1021/acs.jmedchem.3c01088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641827/
https://www.ncbi.nlm.nih.gov/pubmed/37862143
http://dx.doi.org/10.1021/acs.jmedchem.3c01088

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