The Anthelmintic Activity of Praziquantel Analogs Correlates with Structure–Activity Relationships at TRPM(PZQ) Orthologs

[Image: see text] The anthelmintic drug praziquantel remains a key clinical therapy for treating various diseases caused by parasitic flatworms. The parasite target of praziquantel has remained undefined despite longstanding usage in the clinic, although a candidate ion channel target, named TRPM(PZ...

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Detalles Bibliográficos
Autores principales: Sprague, Daniel J., Kaethner, Marc, Park, Sang-Kyu, Rohr, Claudia M., Harris, Jade L., Maillard, David, Spangenberg, Thomas, Lundström-Stadelmann, Britta, Marchant, Jonathan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641913/
https://www.ncbi.nlm.nih.gov/pubmed/37970586
http://dx.doi.org/10.1021/acsmedchemlett.3c00350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641913/
https://www.ncbi.nlm.nih.gov/pubmed/37970586
http://dx.doi.org/10.1021/acsmedchemlett.3c00350

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