Optimization of mTOR Inhibitors Using Property-Based Drug Design and Free–Wilson Analysis for Improved In Vivo Efficacy

[Image: see text] The mTOR kinase regulates a variety of critical cellular processes and has become a target for the treatment of various cancers. Using a combination of property-based drug design and Free–Wilson analysis, we further optimized a series of selective mTOR inhibitors based on the (S)-6...

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Detalles Bibliográficos
Autores principales: Murphy, Sean T., Atienza, Joy, Brown, Jason W., Cheruvallath, Zacharia S., Cukierski, Matthew J., Fabrey, Robyn, Keung, Walter, Kwok, Lily, O’Connell, Shawn, Tang, Mingnam, Vanderpool, Darin L., Vincent, Patrick W., Zhang, Lilly, Marx, Matthew A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641921/
https://www.ncbi.nlm.nih.gov/pubmed/37970587
http://dx.doi.org/10.1021/acsmedchemlett.3c00351

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641921/
https://www.ncbi.nlm.nih.gov/pubmed/37970587
http://dx.doi.org/10.1021/acsmedchemlett.3c00351

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