N-acetylcysteine prevents catheter occlusion and inflammation in catheter associated-urinary tract infections by suppressing urease activity

INTRODUCTION: Proteus mirabilis is a key pathobiont in catheter-associated urinary tract infections (CA-UTIs), which is well known to form crystalline biofilms that occlude catheters. Urease activity alkylates urine through the release of ammonia, consequentially resulting in higher levels of Mg(2+)...

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Detalles Bibliográficos
Autores principales: Manoharan, Arthika, Farrell, Jessica, Aldilla, Vina R., Whiteley, Greg, Kriel, Erik, Glasbey, Trevor, Kumar, Naresh, Moore, Kate H., Manos, Jim, Das, Theerthankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641931/
https://www.ncbi.nlm.nih.gov/pubmed/37965267
http://dx.doi.org/10.3389/fcimb.2023.1216798

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641931/
https://www.ncbi.nlm.nih.gov/pubmed/37965267
http://dx.doi.org/10.3389/fcimb.2023.1216798

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