Cargando…

A selective CB2R agonist (JWH133) protects against pulmonary fibrosis through inhibiting FAK/ERK/S100A4 signaling pathways

BACKGROUND: The combination of the endocannabinoid system (ECS) and the type 2 cannabinoid receptor (CB2R) can activate various signal pathways, leading to distinct pathophysiological roles. This interaction has gained significant attention in recent research on fibrosis diseases. Focal adhesion kin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Xiao, Chen, Lina, Cheng, Yiju, Zhang, Yuquan, Yang, Wenting, Pan, Lin, Fu, Chenkun, Zhu, Honglan, Zhang, Menglin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641936/ https://www.ncbi.nlm.nih.gov/pubmed/37957604 http://dx.doi.org/10.1186/s12890-023-02747-3

Ejemplares similares

Modified Alginate-Based Hydrogel as a Carrier of the CB2 Agonist JWH133 for Bone Engineering
por: Zhou, Wei, et al.
Publicado: (2021)

CB2 Receptor Agonist JWH133 Activates AMPK to Inhibit Growth of C6 Glioma Cells
por: Wang, Feng, et al.
Publicado: (2019)

Treatment with CB(2) Agonist JWH-133 Reduces Histological Features Associated with Erectile Dysfunction in Hypercholesterolemic Mice
por: Fraga-Silva, Rodrigo Araujo, et al.
Publicado: (2013)

Pharmacological Properties, Therapeutic Potential and Molecular Mechanisms of JWH133, a CB2 Receptor-Selective Agonist
por: Hashiesh, Hebaallah Mamdouh, et al.
Publicado: (2021)

Anti-apoptotic and Immunomodulatory Effect of CB2 Agonist, JWH133, in a Neonatal Rat Model of Hypoxic-Ischemic Encephalopathy
por: Gupta, Bhavna, et al.
Publicado: (2020)

Identification of immune biomarkers associated with basement membranes in idiopathic pulmonary fibrosis and their pan-cancer analysis
por: Fu, Chenkun, et al.
Publicado: (2023)

Assessment of the Abuse Liability of Synthetic Cannabinoid Agonists JWH-030, JWH-175, and JWH-176
por: Tampus, Reinholdgher, et al.
Publicado: (2015)

Nintedanib Ameliorates Bleomycin-Induced Pulmonary Fibrosis, Inflammation, Apoptosis, and Oxidative Stress by Modulating PI3K/Akt/mTOR Pathway in Mice
por: Pan, Lin, et al.
Publicado: (2023)

Amifostine attenuates bleomycin-induced pulmonary fibrosis in mice through inhibition of the PI3K/Akt/mTOR signaling pathway
por: Yang, Wenting, et al.
Publicado: (2023)

Anti-Obesity Effect of the CB2 Receptor Agonist JWH-015 in Diet-Induced Obese Mice
por: Verty, A. N. A., et al.
Publicado: (2015)

Activation of cannabinoid receptor type 2 by JWH133 alleviates bleomycin-induced pulmonary fibrosis in mice
por: Fu, Qiang, et al.
Publicado: (2017)

Cannabinoid receptor type 2 agonist JWH-133 decreases cathepsin B secretion and neurotoxicity from HIV-infected macrophages
por: Rosario-Rodríguez, Lester J., et al.
Publicado: (2022)

Neurotoxicity of Synthetic Cannabinoids JWH-081 and JWH-210
por: Cha, Hye Jin, et al.
Publicado: (2015)

Dependence Potential of the Synthetic Cannabinoids JWH-073, JWH-081, and JWH-210: In Vivo and In Vitro Approaches
por: Cha, Hye Jin, et al.
Publicado: (2014)

In Vivo Bio-Activation of JWH-175 to JWH-018: Pharmacodynamic and Pharmacokinetic Studies in Mice
por: Tirri, Micaela, et al.
Publicado: (2022)

Natural (∆(9)-THC) and synthetic (JWH-018) cannabinoids induce seizures by acting through the cannabinoid CB(1) receptor
por: Malyshevskaya, Olga, et al.
Publicado: (2017)

Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R(+)-Methanandamide and JWH-015: Involvement of CB(2)
por: Olea-Herrero, N, et al.
Publicado: (2009)

Data on individual metabolites of synthetic cannabinoids JWH-018, JWH-073 and AM2201 by Cunninghamella elegans
por: Watanabe, Shimpei, et al.
Publicado: (2016)

Chronic Administration of Cannabinoid Receptor 2 Agonist (JWH-133) Increases Ectopic Ovarian Tumor Growth and Endocannabinoids (Anandamide and 2-Arachidonoyl Glycerol) Levels in Immunocompromised SCID Female Mice
por: Blanton, Henry L., et al.
Publicado: (2022)

FAK system: Pulsing into CB test resistor R11
por: Metzmacher, K D
Publicado: (1974)

Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent
por: Hanlon, Katherine E, et al.
Publicado: (2016)

CB(1) Allosteric Modulator Org27569 Is an Antagonist/Inverse Agonist of ERK1/2 Signaling
por: Gamage, Thomas F., et al.
Publicado: (2016)

Behavioral and Pharmacokinetic Profile of Indole-Derived Synthetic Cannabinoids JWH-073 and JWH-210 as Compared to the Phytocannabinoid Δ(9)-THC in Rats
por: Uttl, Libor, et al.
Publicado: (2018)

Acute Pharmacological Effects and Oral Fluid Concentrations of the Synthetic Cannabinoids JWH-122 and JWH-210 in Humans After Self-Administration: An Observational Study
por: Martínez, Lucia, et al.
Publicado: (2021)

Adolescent self-administration of the synthetic cannabinoid receptor agonist JWH-018 induces neurobiological and behavioral alterations in adult male mice
por: Margiani, Giulia, et al.
Publicado: (2022)

CB(1) Cannabinoid Receptors Stimulate Gβγ-GRK2-Mediated FAK Phosphorylation at Tyrosine 925 to Regulate ERK Activation Involving Neuronal Focal Adhesions
por: Dalton, George D., et al.
Publicado: (2020)

Correction to: Adolescent self‑administration of the synthetic cannabinoid receptor agonist JWH‑018 induces neurobiological and behavioral alterations in adult male mice
por: Margiani, Giulia, et al.
Publicado: (2023)

Determination of the Synthetic Cannabinoids JWH-122, JWH-210, UR-144 in Oral Fluid of Consumers by GC-MS and Quantification of Parent Compounds and Metabolites by UHPLC-MS/MS
por: La Maida, Nunzia, et al.
Publicado: (2020)

Cannabinoid CB1 and CB2 Receptor-Mediated Arrestin Translocation: Species, Subtype, and Agonist-Dependence
por: Ibsen, Mikkel Søes, et al.
Publicado: (2019)

Positive Allosteric Modulation of CB1 and CB2 Cannabinoid Receptors Enhances the Neuroprotective Activity of a Dual CB1R/CB2R Orthosteric Agonist
por: Polini, Beatrice, et al.
Publicado: (2020)

Cannabinoid receptor 2-selective agonist JWH015 attenuates bone cancer pain through the amelioration of impaired autophagy flux induced by inflammatory mediators in the spinal cord
por: Mao, Yanting, et al.
Publicado: (2019)

Self-Administration of JWH-018 A Synthetic Cannabinoid in Experimentally Naïve Rats
por: Hiranita, Takato
Publicado: (2015)

Selective Estrogen Receptor Modulators: Cannabinoid Receptor Inverse Agonists with Differential CB1 and CB2 Selectivity
por: Franks, Lirit N., et al.
Publicado: (2016)

Evaluation of carboxamide-type synthetic cannabinoids as CB(1)/CB(2) receptor agonists: difference between the enantiomers
por: Doi, Takahiro, et al.
Publicado: (2017)

Time-Dependent Protection of CB2 Receptor Agonist in Stroke
por: Yu, Seong-Jin, et al.
Publicado: (2015)

Cannabinoid CB1 receptor agonist ACEA alleviates brain ischemia/reperfusion injury via CB1–Drp1 pathway
por: Yang, Shuai, et al.
Publicado: (2020)

Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms
por: Yang, Jianbo, et al.
Publicado: (2004)

Vinculin modulation of paxillin–FAK interactions regulates ERK to control survival and motility
por: Subauste, M. Cecilia, et al.
Publicado: (2004)

Elevation of endocannabinoids in the brain by synthetic cannabinoid JWH-018: mechanism and effect on learning and memory
por: Li, Ren-shi, et al.
Publicado: (2019)

The CB1 cannabinoid receptor agonist reduces L-DOPA-induced motor fluctuation and ERK1/2 phosphorylation in 6-OHDA-lesioned rats
por: Song, Lu, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_imf79bd1ud5ete10rl7qg3cmdd