RIPK1 deficiency prevents thymic NK1.1 expression and subsequent iNKT cell development

Receptor Interacting Protein Kinase 1 (RIPK1) and caspase-8 (Casp8) jointly orchestrate apoptosis, a key mechanism for eliminating developing T cells which have autoreactive or improperly arranged T cell receptors. Mutations in the scaffolding domain of Ripk1 gene have been identified in humans with...

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Detalles Bibliográficos
Autores principales: Hägglöf, Thomas, Parthasarathy, Raksha, Liendo, Nathaniel, Dudley, Elizabeth A., Leadbetter, Elizabeth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642909/
https://www.ncbi.nlm.nih.gov/pubmed/37965338
http://dx.doi.org/10.3389/fimmu.2023.1103591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642909/
https://www.ncbi.nlm.nih.gov/pubmed/37965338
http://dx.doi.org/10.3389/fimmu.2023.1103591

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