Gut microbiota depletion aggravates bile acid-induced liver pathology in mice with a human-like bile acid composition

Cyp2c70-deficient mice have a human-like bile acid (BA) composition due to their inability to convert chenodeoxycholic acid (CDCA) into rodent-specific muricholic acids (MCAs). However, the hydrophobic BA composition in these animals is associated with liver pathology. Although Cyp2c70-ablation has...

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Detalles Bibliográficos
Autores principales: Verkade, Esther, Shen, Wenqiang, Hovingh, Milaine V., Mulder, Niels L., de Bruyn, Krisztina, Koehorst, Martijn, de Vries, Hilde D., Bloks, Vincent W., Kuipers, Folkert, de Boer, Jan Freark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2023
Materias:
Gastrointestinal, Renal & Hepatic Systems
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643054/
https://www.ncbi.nlm.nih.gov/pubmed/37910096
http://dx.doi.org/10.1042/CS20230812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643054/
https://www.ncbi.nlm.nih.gov/pubmed/37910096
http://dx.doi.org/10.1042/CS20230812

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