Hallucination of closed repeat proteins containing central pockets

In pseudocyclic proteins, such as TIM barrels, β barrels, and some helical transmembrane channels, a single subunit is repeated in a cyclic pattern, giving rise to a central cavity that can serve as a pocket for ligand binding or enzymatic activity. Inspired by these proteins, we devised a deep-lear...

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Detalles Bibliográficos
Autores principales: An, Linna, Hicks, Derrick R., Zorine, Dmitri, Dauparas, Justas, Wicky, Basile I. M., Milles, Lukas F., Courbet, Alexis, Bera, Asim K., Nguyen, Hannah, Kang, Alex, Carter, Lauren, Baker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643118/
https://www.ncbi.nlm.nih.gov/pubmed/37770718
http://dx.doi.org/10.1038/s41594-023-01112-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643118/
https://www.ncbi.nlm.nih.gov/pubmed/37770718
http://dx.doi.org/10.1038/s41594-023-01112-6

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