Structure of LRRK1 and mechanisms of autoinhibition and activation

Leucine Rich Repeat Kinase 1 and 2 (LRRK1 and LRRK2) are homologs in the ROCO family of proteins in humans. Despite their shared domain architecture and involvement in intracellular trafficking, their disease associations are strikingly different: LRRK2 is involved in familial Parkinson’s disease wh...

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Detalles Bibliográficos
Autores principales: Reimer, Janice M., Dickey, Andrea M., Lin, Yu Xuan, Abrisch, Robert G., Mathea, Sebastian, Chatterjee, Deep, Fay, Elizabeth J., Knapp, Stefan, Daugherty, Matthew D., Reck-Peterson, Samara L., Leschziner, Andres E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643122/
https://www.ncbi.nlm.nih.gov/pubmed/37857821
http://dx.doi.org/10.1038/s41594-023-01109-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643122/
https://www.ncbi.nlm.nih.gov/pubmed/37857821
http://dx.doi.org/10.1038/s41594-023-01109-1

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