Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation

Ferroptosis, marked by iron-dependent lipid peroxidation, may present an Achilles heel for the treatment of cancers. Ferroptosis suppressor protein-1 (FSP1), as the second ferroptosis mainstay, efficiently prevents lipid peroxidation via NAD(P)H-dependent reduction of quinones. Because its molecular...

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Detalles Bibliográficos
Autores principales: Nakamura, Toshitaka, Mishima, Eikan, Yamada, Naoya, Mourão, André Santos Dias, Trümbach, Dietrich, Doll, Sebastian, Wanninger, Jonas, Lytton, Elena, Sennhenn, Peter, Nishida Xavier da Silva, Thamara, Angeli, José Pedro Friedmann, Sattler, Michael, Proneth, Bettina, Conrad, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643123/
https://www.ncbi.nlm.nih.gov/pubmed/37957306
http://dx.doi.org/10.1038/s41594-023-01136-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643123/
https://www.ncbi.nlm.nih.gov/pubmed/37957306
http://dx.doi.org/10.1038/s41594-023-01136-y

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