Cargando…

Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation

Ferroptosis, marked by iron-dependent lipid peroxidation, may present an Achilles heel for the treatment of cancers. Ferroptosis suppressor protein-1 (FSP1), as the second ferroptosis mainstay, efficiently prevents lipid peroxidation via NAD(P)H-dependent reduction of quinones. Because its molecular...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nakamura, Toshitaka, Mishima, Eikan, Yamada, Naoya, Mourão, André Santos Dias, Trümbach, Dietrich, Doll, Sebastian, Wanninger, Jonas, Lytton, Elena, Sennhenn, Peter, Nishida Xavier da Silva, Thamara, Angeli, José Pedro Friedmann, Sattler, Michael, Proneth, Bettina, Conrad, Marcus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643123/ https://www.ncbi.nlm.nih.gov/pubmed/37957306 http://dx.doi.org/10.1038/s41594-023-01136-y

Ejemplares similares

Phase separation of FSP1 promotes ferroptosis
por: Nakamura, Toshitaka, et al.
Publicado: (2023)

Molecular characterization of AIFM2/FSP1 inhibition by iFSP1-like molecules
por: Xavier da Silva, Thamara Nishida, et al.
Publicado: (2023)

Sorafenib fails to trigger ferroptosis across a wide range of cancer cell lines
por: Zheng, Jiashuo, et al.
Publicado: (2021)

A non-canonical vitamin K cycle is a potent ferroptosis suppressor
por: Mishima, Eikan, et al.
Publicado: (2022)

Structural insights into FSP1 catalysis and ferroptosis inhibition
por: Lv, Yun, et al.
Publicado: (2023)

Glutathione peroxidase 4 (Gpx4) and ferroptosis: what's so special about it?
por: Conrad, Marcus, et al.
Publicado: (2015)

NFE2L1-mediated proteasome function protects from ferroptosis
por: Kotschi, Stefan, et al.
Publicado: (2022)

The CoQ oxidoreductase FSP1 acts in parallel to GPX4 to inhibit ferroptosis
por: Bersuker, Kirill, et al.
Publicado: (2019)

Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals
por: Barayeu, Uladzimir, et al.
Publicado: (2022)

LINC01133 can induce acquired ferroptosis resistance by enhancing the FSP1 mRNA stability through forming the LINC01133-FUS-FSP1 complex
por: Wang, Shaowen, et al.
Publicado: (2023)

Plasma-activated medium induces ferroptosis by depleting FSP1 in human lung cancer cells
por: Jo, Ara, et al.
Publicado: (2022)

Elevated FSP1 protects KRAS-mutated cells from ferroptosis during tumor initiation
por: Müller, Fabienne, et al.
Publicado: (2022)

CD36 promotes tubular ferroptosis by regulating the ubiquitination of FSP1 in acute kidney injury
por: Ma, Yixin, et al.
Publicado: (2023)

FSP meeting at Siegen
Publicado: (2017)

Acute lymphoblastic leukemia necessitates GSH-dependent ferroptosis defenses to overcome FSP1-epigenetic silencing
por: Pontel, Lucas B., et al.
Publicado: (2022)

TRIM21‐Promoted FSP1 Plasma Membrane Translocation Confers Ferroptosis Resistance in Human Cancers
por: Gong, Jun, et al.
Publicado: (2023)

Sorafenib induces ferroptosis by promoting TRIM54-mediated FSP1 ubiquitination and degradation in hepatocellular carcinoma
por: Liu, Man-ru, et al.
Publicado: (2023)

ACSL1-induced ferroptosis and platinum resistance in ovarian cancer by increasing FSP1 N-myristylation and stability
por: Zhang, Qingyu, et al.
Publicado: (2023)

Involvement of FSP1-CoQ(10)-NADH and GSH-GPx-4 pathways in retinal pigment epithelium ferroptosis
por: Yang, Ming, et al.
Publicado: (2022)

UHRF1-mediated ferroptosis promotes pulmonary fibrosis via epigenetic repression of GPX4 and FSP1 genes
por: Liu, Yi, et al.
Publicado: (2022)

FSP1, a novel KEAP1/NRF2 target gene regulating ferroptosis and radioresistance in lung cancers
por: Emmanuel, Nsengiyumva, et al.
Publicado: (2022)

QiLing Decoction promotes ferroptosis of castration-resistant prostate cancer cells by inhibiting FSP1 in vitro and in vivo
por: Cao, Hongwen, et al.
Publicado: (2023)

A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers
por: Koppula, Pranavi, et al.
Publicado: (2022)

HDLBP-stabilized lncFAL inhibits ferroptosis vulnerability by diminishing Trim69-dependent FSP1 degradation in hepatocellular carcinoma
por: Yuan, Jingsheng, et al.
Publicado: (2022)

N‐acetyltransferase 10 promotes colon cancer progression by inhibiting ferroptosis through N4‐acetylation and stabilization of ferroptosis suppressor protein 1 (FSP1) mRNA
por: Zheng, Xiao, et al.
Publicado: (2022)

Lipid droplets fatten up with Fsp27
por: Short, Ben
Publicado: (2011)

DNA methylation-regulated LINC02587 inhibits ferroptosis and promotes the progression of glioma cells through the CoQ-FSP1 pathway
por: Wang, Zhengang, et al.
Publicado: (2023)

FSP1 confers ferroptosis resistance in KEAP1 mutant non-small cell lung carcinoma in NRF2-dependent and -independent manner
por: Kim, Jong Woo, et al.
Publicado: (2023)

Identification and characterization of a fibroblast marker: FSP1
Publicado: (1995)

Gut Microbiota Dynamics and Uremic Toxins
por: Mishima, Eikan, et al.
Publicado: (2022)

Lipoxygenases—Killers against Their Will?
por: Friedmann Angeli, José Pedro, et al.
Publicado: (2018)

Overexpression of FSP1 Ameliorates ferroptosis via PI3K/ AKT /GSK3β pathway in PC12 cells with Oxygen-Glucose Deprivation/Reoxygenation
por: Wu, Yonghui, et al.
Publicado: (2023)

Regulation of gene expression by FSP27 in white and brown adipose tissue
por: Li, De, et al.
Publicado: (2010)

Gene expression profile in the fat tissue of Fsp27 deficient mice
por: Xu, Li, et al.
Publicado: (2015)

Therapeutic silencing of FSP27 reduces the progression of atherosclerosis in Ldlr(−/−) mice
por: Rajamoorthi, Ananthi, et al.
Publicado: (2018)

FSP1-positive fibroblasts are adipogenic niche and regulate adipose homeostasis
por: Zhang, Rui, et al.
Publicado: (2018)

Effect of FSP on Tribological Properties of Grade B89 Tin Babbitt
por: Madej, Marcin, et al.
Publicado: (2021)

ENCoRE: an efficient software for CRISPR screens identifies new players in extrinsic apoptosis
por: Trümbach, Dietrich, et al.
Publicado: (2017)

FSP27 Promotes Lipid Droplet Clustering and Then Fusion to Regulate Triglyceride Accumulation
por: Jambunathan, Srikarthika, et al.
Publicado: (2011)

The anti-ferroptotic role of FSP1: current molecular mechanism and therapeutic approach
por: Zeng, Furong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_73pusd6apmulu28c725lgeommk