Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C)

Substrate polyubiquitination drives a myriad of cellular processes, including the cell cycle, apoptosis and immune responses. Polyubiquitination is highly dynamic, and obtaining mechanistic insight has thus far required artificially trapped structures to stabilize specific steps along the enzymatic...

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Detalles Bibliográficos
Autores principales: Bodrug, Tatyana, Welsh, Kaeli A., Bolhuis, Derek L., Paulаkonis, Ethan, Martinez-Chacin, Raquel C., Liu, Bei, Pinkin, Nicholas, Bonacci, Thomas, Cui, Liying, Xu, Pengning, Roscow, Olivia, Amann, Sascha Josef, Grishkovskaya, Irina, Emanuele, Michael J., Harrison, Joseph S., Steimel, Joshua P., Hahn, Klaus M., Zhang, Wei, Zhong, Ellen D., Haselbach, David, Brown, Nicholas G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643132/
https://www.ncbi.nlm.nih.gov/pubmed/37735619
http://dx.doi.org/10.1038/s41594-023-01105-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643132/
https://www.ncbi.nlm.nih.gov/pubmed/37735619
http://dx.doi.org/10.1038/s41594-023-01105-5

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