Aberrant gene activation in synovial sarcoma relies on SSX specificity and increased PRC1.1 stability

The SS18-SSX fusion drives oncogenic transformation in synovial sarcoma by bridging SS18, a member of the mSWI/SNF (BAF) complex, to Polycomb repressive complex 1 (PRC1) target genes. Here we show that the ability of SS18-SSX to occupy H2AK119ub1-rich regions is an intrinsic property of its SSX C te...

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Detalles Bibliográficos
Autores principales: Benabdallah, Nezha S., Dalal, Vineet, Scott, R. Wilder, Marcous, Fady, Sotiriou, Afroditi, Kommoss, Felix K. F., Pejkovska, Anastasija, Gaspar, Ludmila, Wagner, Lena, Sánchez-Rivera, Francisco J., Ta, Monica, Thornton, Shelby, Nielsen, Torsten O., Underhill, T. Michael, Banito, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643139/
https://www.ncbi.nlm.nih.gov/pubmed/37735617
http://dx.doi.org/10.1038/s41594-023-01096-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643139/
https://www.ncbi.nlm.nih.gov/pubmed/37735617
http://dx.doi.org/10.1038/s41594-023-01096-3

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