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Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane

Defects in plasma membrane repair can lead to muscle and heart diseases in humans. Tripartite motif-containing protein (TRIM)72 (mitsugumin 53; MG53) has been determined to rapidly nucleate vesicles at the site of membrane damage, but the underlying molecular mechanisms remain poorly understood. Her...

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Detalles Bibliográficos
Autores principales: Park, Si Hoon, Han, Juhyun, Jeong, Byung-Cheon, Song, Ju Han, Jang, Se Hwan, Jeong, Hyeongseop, Kim, Bong Heon, Ko, Young-Gyu, Park, Zee-Yong, Lee, Kyung Eun, Hyun, Jaekyung, Song, Hyun Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643145/
https://www.ncbi.nlm.nih.gov/pubmed/37770719
http://dx.doi.org/10.1038/s41594-023-01111-7