OR-1896 increases force of contraction in the isolated human atrium

OR-1896 ((R)-N-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)acetamide) is the main active metabolite of levosimendan. However, nobody has reported a positive inotropic effect of OR-1896 in isolated human cardiac preparations. The mechanism of action of OR-1896 remains controversial. He...

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Detalles Bibliográficos
Autores principales: Rayo-Abella, Lina M., Grundig, Peter, Bernhardt, Max N., Hofmann, Britt, Neumann, Joachim, Gergs, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643428/
https://www.ncbi.nlm.nih.gov/pubmed/37354216
http://dx.doi.org/10.1007/s00210-023-02592-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643428/
https://www.ncbi.nlm.nih.gov/pubmed/37354216
http://dx.doi.org/10.1007/s00210-023-02592-5

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