Characterization of novel mouse models to study the role of necroptosis in aging and age-related diseases

To study the impact of necroptosis-induced chronic inflammation on age-related diseases and aging, two knockin mouse models (Ripk3-KI and Mlkl-KI) were generated that overexpress two genes involved in necroptosis (Ripk3 or Mlkl) when crossed to Cre transgenic mice. Crossing Ripk3-KI or Mlkl-KI mice...

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Detalles Bibliográficos
Autores principales: Selvarani, Ramasamy, Van Michelle Nguyen, Hoang, Thadathil, Nidheesh, Wolf, Roman F., Freeman, Willard M., Wiley, Christopher D., Deepa, Sathyaseelan S., Richardson, Arlan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643444/
https://www.ncbi.nlm.nih.gov/pubmed/37792157
http://dx.doi.org/10.1007/s11357-023-00955-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643444/
https://www.ncbi.nlm.nih.gov/pubmed/37792157
http://dx.doi.org/10.1007/s11357-023-00955-7

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