Insights into the mechanism of SARS-CoV-2 main protease autocatalytic maturation from model precursors

A critical step for SARS-CoV-2 assembly and maturation involves the autoactivation of the main protease (MPro(WT)) from precursor polyproteins. Upon expression, a model precursor of MPro(WT) mediates its own release at its termini rapidly to yield a mature dimer. A construct with an E290A mutation w...

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Detalles Bibliográficos
Autores principales: Aniana, Annie, Nashed, Nashaat T., Ghirlando, Rodolfo, Coates, Leighton, Kneller, Daniel W., Kovalevsky, Andrey, Louis, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643566/
https://www.ncbi.nlm.nih.gov/pubmed/37957287
http://dx.doi.org/10.1038/s42003-023-05469-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643566/
https://www.ncbi.nlm.nih.gov/pubmed/37957287
http://dx.doi.org/10.1038/s42003-023-05469-8

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