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Detection and therapeutic implications of homologous recombination repair deficiency in pancreatic cancer: a narrative review

BACKGROUND AND OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers. A major recent advance has been the identification of a subset of patients with PDAC who harbor inherited or somatic genetic alterations that result in homologous recombination deficiency (HRD)...

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Detalles Bibliográficos
Autores principales: Tan, Heng, Hosein, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643583/
https://www.ncbi.nlm.nih.gov/pubmed/37969835
http://dx.doi.org/10.21037/jgo-23-85