UBE4B interacts with the ITCH E3 ubiquitin ligase to induce Ku70 and c-FLIPL polyubiquitination and enhanced neuroblastoma apoptosis

Expression of the UBE4B ubiquitin ligase is strongly associated with neuroblastoma patient outcomes, but the functional roles of UBE4B in neuroblastoma pathogenesis are not known. We evaluated interactions of UBE4B with the E3 ubiquitin ligase ITCH/AIP4 and the effects of UBE4B expression on Ku70 an...

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Detalles Bibliográficos
Autores principales: Le Clorennec, Christophe, Subramonian, Divya, Huo, Yuchen, Zage, Peter E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643674/
https://www.ncbi.nlm.nih.gov/pubmed/37957138
http://dx.doi.org/10.1038/s41419-023-06252-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643674/
https://www.ncbi.nlm.nih.gov/pubmed/37957138
http://dx.doi.org/10.1038/s41419-023-06252-7

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