Cargando…

Ex vivo and in vitro Monocyte Responses Do Not Reflect in vivo Immune Responses and Tolerance

Cytokine production by ex vivo (EV)-stimulated leukocytes is commonly used to gauge immune function and frequently proposed to guide immunomodulatory therapy. However, whether EV cytokine production capacity accurately reflects the in vivo (IV) immune status is largely unknown. We investigated relat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jansen, Aron, Bruse, Niklas, Waalders, Nicole, Gerretsen, Jelle, Rijbroek, Daniëlle, Pickkers, Peter, Kox, Matthijs
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	S. Karger AG 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643897/ https://www.ncbi.nlm.nih.gov/pubmed/35940121 http://dx.doi.org/10.1159/000525572

Ejemplares similares

CytoSorb hemoperfusion markedly attenuates circulating cytokine concentrations during systemic inflammation in humans in vivo
por: Jansen, Aron, et al.
Publicado: (2023)

Treatment With Acetylsalicylic Acid Reverses Endotoxin Tolerance in Humans In Vivo: A Randomized Placebo-Controlled Study
por: Leijte, Guus P., et al.
Publicado: (2019)

Comparison of different lots of endotoxin and evaluation of in vivo potency over time in the experimental human endotoxemia model
por: Kiers, Dorien, et al.
Publicado: (2019)

Short-term repeated HRV-16 exposure results in an attenuated immune response in vivo in humans
por: Koch, Rebecca M., et al.
Publicado: (2018)

Frontline Science: Endotoxin‐induced immunotolerance is associated with loss of monocyte metabolic plasticity and reduction of oxidative burst
por: Grondman, Inge, et al.
Publicado: (2019)

The Effects of Orally Administered Beta-Glucan on Innate Immune Responses in Humans, a Randomized Open-Label Intervention Pilot-Study
por: Leentjens, Jenneke, et al.
Publicado: (2014)

Development of Endotoxin Tolerance Does Not Influence the Response to a Challenge with the Mucosal Live-Attenuated Influenza Vaccine in Humans In Vivo
por: Koch, Rebecca M., et al.
Publicado: (2017)

Effect of anakinra in COVID-19
por: Kooistra, Emma J, et al.
Publicado: (2020)

Monocytic HLA-DR expression kinetics in septic shock patients with different pathogens, sites of infection and adverse outcomes
por: Leijte, Guus P., et al.
Publicado: (2020)

0095. Transvenous vagus nerve stimulation does not modulate the innate immune response in humans in vivo during experimental endotoxemia
por: Kox, M, et al.
Publicado: (2014)

A randomized double‐blind, placebo‐controlled clinical phase IIa trial on safety, immunomodulatory effects and pharmacokinetics of EA‐230 during experimental human endotoxaemia
por: van Groenendael, Roger, et al.
Publicado: (2019)

No interplay between gut microbiota composition and the lipopolysaccharide‐induced innate immune response in humans in vivo
por: Habes, Quirine LM, et al.
Publicado: (2021)

The Effects of Cold Exposure Training and a Breathing Exercise on the Inflammatory Response in Humans: A Pilot Study
por: Zwaag, Jelle, et al.
Publicado: (2022)

Transvenous vagus nerve stimulation does not modulate the innate immune response during experimental human endotoxemia: a randomized controlled study
por: Kox, Matthijs, et al.
Publicado: (2015)

0900. Effects of oxygen status on the innate immune response in humans in vivo
por: Kiers, D, et al.
Publicado: (2014)

Does subarachnoid haemorrhage affect the innate immune response?
por: Kox, Matthijs, et al.
Publicado: (2007)

Increased Plasma Levels of Danger-Associated Molecular Patterns Are Associated With Immune Suppression and Postoperative Infections in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
por: Leijte, Guus P., et al.
Publicado: (2018)

Clinical sepsis phenotypes in critically ill COVID-19 patients
por: Bruse, Niklas, et al.
Publicado: (2022)

Modulation of Pain Sensitivity by a Hyperventilatory Breathing Exercise and Cold Exposure Training
por: Zwaag, Jelle, et al.
Publicado: (2023)

The effect of temperature and heat shock protein 72 on the ex vivo acute inflammatory response in monocytes
por: Hoekstra, Sven P., et al.
Publicado: (2019)

Characterization of a model of systemic inflammation in humans in vivo elicited by continuous infusion of endotoxin
por: Kiers, D., et al.
Publicado: (2017)

Short-term hyperoxia does not exert immunologic effects during experimental murine and human endotoxemia
por: Kiers, Dorien, et al.
Publicado: (2015)

Classical monocytes maintain ex vivo glycolytic metabolism and early but not later inflammatory responses in older adults
por: Pence, Brandt D., et al.
Publicado: (2019)

Trained Circulating Monocytes in Atherosclerosis: Ex Vivo Model Approach
por: Nikiforov, Nikita G., et al.
Publicado: (2019)

Tolerizing Strategies for the Treatment of Autoimmune Diseases: From ex vivo to in vivo Strategies
por: Cauwels, Anje, et al.
Publicado: (2020)

Human rhinovirus infection induces local and systemic immunological tolerance in healthy volunteers
por: Koch, RM, et al.
Publicado: (2015)

Ex vivo treatment of prostate tumor tissue recapitulates in vivo therapy response
por: Zhang, Wenhao, et al.
Publicado: (2018)

Inhibiting ex-vivo Th17 responses in Ankylosing Spondylitis by targeting Janus kinases
por: Hammitzsch, Ariane, et al.
Publicado: (2018)

Endotoxemia-Induced Release of Pro-inflammatory Mediators Are Associated With Increased Glomerular Filtration Rate in Humans in vivo
por: Beunders, Remi, et al.
Publicado: (2020)

Adrenomedullin: its double-edged sword during sepsis slices yet again
por: Kox, Matthijs, et al.
Publicado: (2014)

Towards precision medicine for sepsis patients
por: Pickkers, Peter, et al.
Publicado: (2017)

Pharmacokinetics, safety and tolerability of the novel β‐hCG derived immunomodulatory compound, EA‐230
por: van Groenendael, Roger, et al.
Publicado: (2019)

Functional Ex Vivo Testing of Alveolar Monocytes in Patients with Pneumonia-Related ARDS
por: Bendib, Inès, et al.
Publicado: (2021)

Injectable Magnetic-Responsive Short-Peptide Supramolecular Hydrogels: Ex Vivo and In Vivo Evaluation
por: Mañas-Torres, Mari C., et al.
Publicado: (2021)

Systemic Inflammation Decreases Pain Threshold in Humans In Vivo
por: de Goeij, Moniek, et al.
Publicado: (2013)

Brainstem anatomy with 7-T MRI: in vivo assessment and ex vivo comparison
por: Donatelli, Graziella, et al.
Publicado: (2023)

The role of outcome expectancies for a training program consisting of meditation, breathing exercises, and cold exposure on the response to endotoxin administration: a proof-of-principle study
por: van Middendorp, Henriët, et al.
Publicado: (2015)

Visible near infrared reflectance molecular chemical imaging of human ex vivo carcinomas and murine in vivo carcinomas
por: Stewart, Shona, et al.
Publicado: (2020)

Ex Vivo Host and Parasite Response to Antileishmanial Drugs and Immunomodulators
por: Gonzalez-Fajardo, Laura, et al.
Publicado: (2015)

Response of Chondrocytes to Local Mechanical Injury in an Ex Vivo Model
por: Lyman, Jeffrey R., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_8js81f4bvlp101ph5uephbrgc8