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The transcription activity of OTX2 on p16 expression is significantly blocked by methylation of CpG shore in non-promoter of lung cancer cell lines
BACKGROUND: The aberrant expression of the classical tumor suppressor gene p16 is a frequent event in lung cancer mainly due to the hypermethylation of its 5’-cytosine-phosphate-guanine-3’ island (Cgi). However, whether methylation happens in other regions and how p16 expression and function are aff...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643975/ https://www.ncbi.nlm.nih.gov/pubmed/37969391 http://dx.doi.org/10.21037/tcr-23-909 |