The transcription activity of OTX2 on p16 expression is significantly blocked by methylation of CpG shore in non-promoter of lung cancer cell lines

BACKGROUND: The aberrant expression of the classical tumor suppressor gene p16 is a frequent event in lung cancer mainly due to the hypermethylation of its 5’-cytosine-phosphate-guanine-3’ island (Cgi). However, whether methylation happens in other regions and how p16 expression and function are aff...

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Detalles Bibliográficos
Autores principales: Peng, Honghao, Fu, Wenfan, Chang, Chong, Gao, Huan, He, Qianmei, Liu, Ziqi, Cui, Mengxing, Wang, Han, Yu, Yongjiang, Wu, Yonghui, Zhang, Xue, Jiang, Shuyun, Xu, Chi, Shen, Xiaoyu, Zhang, Zhihan, Zhou, Yixiang, Li, Daochuan, Wang, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643975/
https://www.ncbi.nlm.nih.gov/pubmed/37969391
http://dx.doi.org/10.21037/tcr-23-909

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