Skin microbiome profile in people living with HIV/AIDS in Cameroon
The presence of pathogens and the state of diseases, particularly skin diseases, may alter the composition of human skin microbiome. HIV infection has been reported to impair gut microbiome that leads to severe consequences. However, with cutaneous manifestations, that can be life-threatening, due t...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644231/ https://www.ncbi.nlm.nih.gov/pubmed/38029259 http://dx.doi.org/10.3389/fcimb.2023.1211899 |
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author | Ogai, Kazuhiro Nana, Benderli Christine Lloyd, Yukie Michelle Arios, John Paul Jiyarom, Boonyanudh Awanakam, Honore Esemu, Livo Forgu Hori, Aki Matsuoka, Ayaka Nainu, Firzan Megnekou, Rosette Leke, Rose Gana Fomban Ekali, Gabriel Loni Okamoto, Shigefumi Kuraishi, Takayuki |
author_facet | Ogai, Kazuhiro Nana, Benderli Christine Lloyd, Yukie Michelle Arios, John Paul Jiyarom, Boonyanudh Awanakam, Honore Esemu, Livo Forgu Hori, Aki Matsuoka, Ayaka Nainu, Firzan Megnekou, Rosette Leke, Rose Gana Fomban Ekali, Gabriel Loni Okamoto, Shigefumi Kuraishi, Takayuki |
author_sort | Ogai, Kazuhiro |
collection | PubMed |
description | The presence of pathogens and the state of diseases, particularly skin diseases, may alter the composition of human skin microbiome. HIV infection has been reported to impair gut microbiome that leads to severe consequences. However, with cutaneous manifestations, that can be life-threatening, due to the opportunistic pathogens, little is known whether HIV infection might influence the skin microbiome and affect the skin homeostasis. This study catalogued the profile of skin microbiome of healthy Cameroonians, at three different skin sites, and compared them to the HIV-infected individuals. Taking advantage on the use of molecular assay coupled with next-generation sequencing, this study revealed that alpha-diversity of the skin microbiome was higher and beta-diversity was altered significantly in the HIV-infected Cameroonians than in the healthy ones. The relative abundance of skin microbes such as Micrococcus and Kocuria species was higher and Cutibacterium species was significantly lower in HIV-infected people, indicating an early change in the human skin microbiome in response to the HIV infection. This phenotypical shift was not related to the number of CD4 T cell count thus the cause remains to be identified. Overall, these data may offer an important lead on the role of skin microbiome in the determination of cutaneous disease state and the discovery of safe pharmacological preparations to treat microbial-related skin disorders. |
format | Online Article Text |
id | pubmed-10644231 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106442312023-01-01 Skin microbiome profile in people living with HIV/AIDS in Cameroon Ogai, Kazuhiro Nana, Benderli Christine Lloyd, Yukie Michelle Arios, John Paul Jiyarom, Boonyanudh Awanakam, Honore Esemu, Livo Forgu Hori, Aki Matsuoka, Ayaka Nainu, Firzan Megnekou, Rosette Leke, Rose Gana Fomban Ekali, Gabriel Loni Okamoto, Shigefumi Kuraishi, Takayuki Front Cell Infect Microbiol Cellular and Infection Microbiology The presence of pathogens and the state of diseases, particularly skin diseases, may alter the composition of human skin microbiome. HIV infection has been reported to impair gut microbiome that leads to severe consequences. However, with cutaneous manifestations, that can be life-threatening, due to the opportunistic pathogens, little is known whether HIV infection might influence the skin microbiome and affect the skin homeostasis. This study catalogued the profile of skin microbiome of healthy Cameroonians, at three different skin sites, and compared them to the HIV-infected individuals. Taking advantage on the use of molecular assay coupled with next-generation sequencing, this study revealed that alpha-diversity of the skin microbiome was higher and beta-diversity was altered significantly in the HIV-infected Cameroonians than in the healthy ones. The relative abundance of skin microbes such as Micrococcus and Kocuria species was higher and Cutibacterium species was significantly lower in HIV-infected people, indicating an early change in the human skin microbiome in response to the HIV infection. This phenotypical shift was not related to the number of CD4 T cell count thus the cause remains to be identified. Overall, these data may offer an important lead on the role of skin microbiome in the determination of cutaneous disease state and the discovery of safe pharmacological preparations to treat microbial-related skin disorders. Frontiers Media S.A. 2023-10-31 /pmc/articles/PMC10644231/ /pubmed/38029259 http://dx.doi.org/10.3389/fcimb.2023.1211899 Text en Copyright © 2023 Ogai, Nana, Lloyd, Arios, Jiyarom, Awanakam, Esemu, Hori, Matsuoka, Nainu, Megnekou, Leke, Ekali, Okamoto and Kuraishi https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Ogai, Kazuhiro Nana, Benderli Christine Lloyd, Yukie Michelle Arios, John Paul Jiyarom, Boonyanudh Awanakam, Honore Esemu, Livo Forgu Hori, Aki Matsuoka, Ayaka Nainu, Firzan Megnekou, Rosette Leke, Rose Gana Fomban Ekali, Gabriel Loni Okamoto, Shigefumi Kuraishi, Takayuki Skin microbiome profile in people living with HIV/AIDS in Cameroon |
title | Skin microbiome profile in people living with HIV/AIDS in Cameroon |
title_full | Skin microbiome profile in people living with HIV/AIDS in Cameroon |
title_fullStr | Skin microbiome profile in people living with HIV/AIDS in Cameroon |
title_full_unstemmed | Skin microbiome profile in people living with HIV/AIDS in Cameroon |
title_short | Skin microbiome profile in people living with HIV/AIDS in Cameroon |
title_sort | skin microbiome profile in people living with hiv/aids in cameroon |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644231/ https://www.ncbi.nlm.nih.gov/pubmed/38029259 http://dx.doi.org/10.3389/fcimb.2023.1211899 |
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