Skin microbiome profile in people living with HIV/AIDS in Cameroon

The presence of pathogens and the state of diseases, particularly skin diseases, may alter the composition of human skin microbiome. HIV infection has been reported to impair gut microbiome that leads to severe consequences. However, with cutaneous manifestations, that can be life-threatening, due t...

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Autores principales: Ogai, Kazuhiro, Nana, Benderli Christine, Lloyd, Yukie Michelle, Arios, John Paul, Jiyarom, Boonyanudh, Awanakam, Honore, Esemu, Livo Forgu, Hori, Aki, Matsuoka, Ayaka, Nainu, Firzan, Megnekou, Rosette, Leke, Rose Gana Fomban, Ekali, Gabriel Loni, Okamoto, Shigefumi, Kuraishi, Takayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644231/
https://www.ncbi.nlm.nih.gov/pubmed/38029259
http://dx.doi.org/10.3389/fcimb.2023.1211899
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author Ogai, Kazuhiro
Nana, Benderli Christine
Lloyd, Yukie Michelle
Arios, John Paul
Jiyarom, Boonyanudh
Awanakam, Honore
Esemu, Livo Forgu
Hori, Aki
Matsuoka, Ayaka
Nainu, Firzan
Megnekou, Rosette
Leke, Rose Gana Fomban
Ekali, Gabriel Loni
Okamoto, Shigefumi
Kuraishi, Takayuki
author_facet Ogai, Kazuhiro
Nana, Benderli Christine
Lloyd, Yukie Michelle
Arios, John Paul
Jiyarom, Boonyanudh
Awanakam, Honore
Esemu, Livo Forgu
Hori, Aki
Matsuoka, Ayaka
Nainu, Firzan
Megnekou, Rosette
Leke, Rose Gana Fomban
Ekali, Gabriel Loni
Okamoto, Shigefumi
Kuraishi, Takayuki
author_sort Ogai, Kazuhiro
collection PubMed
description The presence of pathogens and the state of diseases, particularly skin diseases, may alter the composition of human skin microbiome. HIV infection has been reported to impair gut microbiome that leads to severe consequences. However, with cutaneous manifestations, that can be life-threatening, due to the opportunistic pathogens, little is known whether HIV infection might influence the skin microbiome and affect the skin homeostasis. This study catalogued the profile of skin microbiome of healthy Cameroonians, at three different skin sites, and compared them to the HIV-infected individuals. Taking advantage on the use of molecular assay coupled with next-generation sequencing, this study revealed that alpha-diversity of the skin microbiome was higher and beta-diversity was altered significantly in the HIV-infected Cameroonians than in the healthy ones. The relative abundance of skin microbes such as Micrococcus and Kocuria species was higher and Cutibacterium species was significantly lower in HIV-infected people, indicating an early change in the human skin microbiome in response to the HIV infection. This phenotypical shift was not related to the number of CD4 T cell count thus the cause remains to be identified. Overall, these data may offer an important lead on the role of skin microbiome in the determination of cutaneous disease state and the discovery of safe pharmacological preparations to treat microbial-related skin disorders.
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spelling pubmed-106442312023-01-01 Skin microbiome profile in people living with HIV/AIDS in Cameroon Ogai, Kazuhiro Nana, Benderli Christine Lloyd, Yukie Michelle Arios, John Paul Jiyarom, Boonyanudh Awanakam, Honore Esemu, Livo Forgu Hori, Aki Matsuoka, Ayaka Nainu, Firzan Megnekou, Rosette Leke, Rose Gana Fomban Ekali, Gabriel Loni Okamoto, Shigefumi Kuraishi, Takayuki Front Cell Infect Microbiol Cellular and Infection Microbiology The presence of pathogens and the state of diseases, particularly skin diseases, may alter the composition of human skin microbiome. HIV infection has been reported to impair gut microbiome that leads to severe consequences. However, with cutaneous manifestations, that can be life-threatening, due to the opportunistic pathogens, little is known whether HIV infection might influence the skin microbiome and affect the skin homeostasis. This study catalogued the profile of skin microbiome of healthy Cameroonians, at three different skin sites, and compared them to the HIV-infected individuals. Taking advantage on the use of molecular assay coupled with next-generation sequencing, this study revealed that alpha-diversity of the skin microbiome was higher and beta-diversity was altered significantly in the HIV-infected Cameroonians than in the healthy ones. The relative abundance of skin microbes such as Micrococcus and Kocuria species was higher and Cutibacterium species was significantly lower in HIV-infected people, indicating an early change in the human skin microbiome in response to the HIV infection. This phenotypical shift was not related to the number of CD4 T cell count thus the cause remains to be identified. Overall, these data may offer an important lead on the role of skin microbiome in the determination of cutaneous disease state and the discovery of safe pharmacological preparations to treat microbial-related skin disorders. Frontiers Media S.A. 2023-10-31 /pmc/articles/PMC10644231/ /pubmed/38029259 http://dx.doi.org/10.3389/fcimb.2023.1211899 Text en Copyright © 2023 Ogai, Nana, Lloyd, Arios, Jiyarom, Awanakam, Esemu, Hori, Matsuoka, Nainu, Megnekou, Leke, Ekali, Okamoto and Kuraishi https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Ogai, Kazuhiro
Nana, Benderli Christine
Lloyd, Yukie Michelle
Arios, John Paul
Jiyarom, Boonyanudh
Awanakam, Honore
Esemu, Livo Forgu
Hori, Aki
Matsuoka, Ayaka
Nainu, Firzan
Megnekou, Rosette
Leke, Rose Gana Fomban
Ekali, Gabriel Loni
Okamoto, Shigefumi
Kuraishi, Takayuki
Skin microbiome profile in people living with HIV/AIDS in Cameroon
title Skin microbiome profile in people living with HIV/AIDS in Cameroon
title_full Skin microbiome profile in people living with HIV/AIDS in Cameroon
title_fullStr Skin microbiome profile in people living with HIV/AIDS in Cameroon
title_full_unstemmed Skin microbiome profile in people living with HIV/AIDS in Cameroon
title_short Skin microbiome profile in people living with HIV/AIDS in Cameroon
title_sort skin microbiome profile in people living with hiv/aids in cameroon
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644231/
https://www.ncbi.nlm.nih.gov/pubmed/38029259
http://dx.doi.org/10.3389/fcimb.2023.1211899
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