Kinetic modelling of sterol transport between plasma membrane and endo-lysosomes based on quantitative fluorescence and X-ray imaging data

Niemann Pick type C1 and C2 (NPC1 and NPC2) are two sterol-binding proteins which, together, orchestrate cholesterol transport through late endosomes and lysosomes (LE/LYSs). NPC2 can facilitate sterol exchange between model membranes severalfold, but how this is connected to its function in cells i...

Descripción completa

Detalles Bibliográficos
Autores principales: Wüstner, Daniel, Dupont Juhl, Alice, Egebjerg, Jacob Marcus, Werner, Stephan, McNally, James, Schneider, Gerd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644255/
https://www.ncbi.nlm.nih.gov/pubmed/38020900
http://dx.doi.org/10.3389/fcell.2023.1144936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644255/
https://www.ncbi.nlm.nih.gov/pubmed/38020900
http://dx.doi.org/10.3389/fcell.2023.1144936

Ejemplares similares