Improved Antibacterial Activity of 1,3,4-Oxadiazole-Based Compounds That Restrict Staphylococcus aureus Growth Independent of LtaS Function

[Image: see text] The lipoteichoic acid (LTA) biosynthesis pathway has emerged as a promising antimicrobial therapeutic target. Previous studies identified the 1,3,4 oxadiazole compound 1771 as an LTA inhibitor with activity against Gram-positive pathogens. We have succeeded in making six 1771 deriv...

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Detalles Bibliográficos
Autores principales: Douglas, Edward J. A., Marshall, Brandon, Alghamadi, Arwa, Joseph, Erin A., Duggan, Seána, Vittorio, Serena, De Luca, Laura, Serpi, Michaela, Laabei, Maisem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644342/
https://www.ncbi.nlm.nih.gov/pubmed/37828912
http://dx.doi.org/10.1021/acsinfecdis.3c00250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644342/
https://www.ncbi.nlm.nih.gov/pubmed/37828912
http://dx.doi.org/10.1021/acsinfecdis.3c00250

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