Prevention of Alzheimer Pathology by Blocking Neuregulin Signaling on Microglia

Plaque formation, microglial activation, and synaptic loss are pathologic hallmarks of Alzheimer’s disease; however, removing plaques has had little clinical benefit. Here, we show that neuregulin-1, a glial growth factor, induces inflammatory cytokines and promotes phagocytic activity in vitro and...

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Detalles Bibliográficos
Autores principales: Liu, Jianguo, Geraghty, Joseph R., Schram, Sarah, Cropper, Haley C., Lei, Justin, Loeb, Jeffrey A., Song, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2023
Materias:
Research Article: New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644371/
https://www.ncbi.nlm.nih.gov/pubmed/37903620
http://dx.doi.org/10.1523/ENEURO.0422-23.2023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644371/
https://www.ncbi.nlm.nih.gov/pubmed/37903620
http://dx.doi.org/10.1523/ENEURO.0422-23.2023

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